ArticleIrish journal of medical science2026
The functional burden of chronic urticaria: Sleep quality, activity impairment and work productivity.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic urticaria (CU) is associated with a substantial disease burden extending beyond cutaneous manifestations. It may impair psychological well-being, sleep quality, daily functioning, and work productivity, although these domains have rarely been evaluated simultaneously.
aimTo investigate sleep quality, psychological status, activity impairment, and work productivity in patients with chronic urticaria and identify factors independently associated with the disease.
methodsThis cross-sectional case-control study included 108 patients with chronic urticaria and 95 healthy controls. Sleep quality, psychological status, and work productivity were assessed using the Pittsburgh Sleep Quality Index (PSQI), Depression Anxiety Stress Scale-21 (DASS-21), and Work Productivity and Activity Impairment Questionnaire (WPAI). Multivariable logistic regression analysis was performed to identify factors independently associated with chronic urticaria.
resultsPatients with chronic urticaria had significantly poorer sleep quality, higher depression and anxiety scores, and greater activity impairment than controls (all p < 0.05). In multivariable analysis, higher PSQI, depression, stress, and activity impairment scores were independently associated with chronic urticaria (all p < 0.05). Among employed participants, absenteeism, presenteeism, and overall work productivity impairment were significantly greater in patients (all p < 0.001).
conclusionChronic urticaria is associated with impaired sleep quality, psychological distress, activity impairment, and reduced work productivity. These findings highlight the multidimensional burden of the disease and support a holistic, patient-centred approach to its management.
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