Evidence map›Paper›PMID 42891761›Full record

ArticleBiogerontology2026

Effects of Finasteride exposure on lifespan and locomotor phenotypes.

Keyao Long, Keyi Mo, Kai Xu, Xiaojing Yang, Xiangmin Xu, Su Wang, Menglong Rui

Abstract read
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In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Keyao LongDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China.
Keyi MoDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China.
Kai XuDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China.
Xiaojing YangDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China.
Xiangmin XuDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China.
Su WangDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China. wangsu@seu.edu.cn.
Menglong RuiDepartment of Neurosurgery, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Science and Technology, Institute of Microphysiological Systems, Zhongda Hospital, Southeast University, Nanjing, 210096, China. ruimenglong@seu.edu.cn.ORCID https://orcid.org/0000-0002-1911-8397

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Finasteride is one of the core medications for treating androgen-associated diseases in men. It exhibits multiple therapeutic functions, including inhibiting 5α-reductase, reducing dihydrotestosterone levels, and improving conditions, including prostate enlargement and hair loss. Using Drosophila as the primary model and a mouse behavioral assay as a complementary approach, we combined developmental and behavioral assessments, morphological analyses of motor and sensory neurons, transcriptomics, and genetic methods to investigate developmental, neuronal, and behavioral changes associated with Finasteride exposure and explore their potential molecular basis. Our results indicate that Finasteride exposure is associated with increased intestinal reactive oxygen species (ROS) accumulation and shortened lifespan in both sexes, together with significantly reduced starvation resistance in males. In addition, Finasteride exposure was also associated with altered neuromuscular junction (NMJ) morphology, reduced locomotor performance, and decreased cask expression. Motor-neuron CASK overexpression improved NMJ morphology and locomotor performance in Finasteride-exposed flies. Overall, this study reveals changes in lifespan and locomotor phenotypes associated with Finasteride exposure and further highlights the importance of investigating its broader biological effects in other experimental systems.

Indexed as

5-alpha Reductase InhibitorsFinasterideLocomotionLongevityAnimalsDrosophila melanogasterFemaleMaleMiceNeuromuscular JunctionPhenotypeReactive Oxygen Species5-alpha Reductase InhibitorsFinasterideReactive Oxygen SpeciesClass IV dendritic arborization (C4da) sensory neuronDrosophila melanogasterLocomotor activityNeuromuscular junction (NMJ)Toxicology

Identifiers

PMID42891761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.