Evidence map›Paper›PMID 42891725›Full record

ArticleClinical & experimental metastasis2026

THINKERS-X: multisequence MRI radiomics in a mixture-of-experts model for outcome prediction and exploratory dose-scenario evaluation in lung cancer brain metastases treated with radiosurgery.

Jheremy S Reyes, Constantinos G Hadjipanayis, Ajay Niranjan

Abstract read
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Article in Clinical & experimental metastasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Jheremy S ReyesDepartment of Neurological Surgery, Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Constantinos G HadjipanayisDepartment of Neurological Surgery, Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ajay NiranjanDepartment of Neurological Surgery, Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. niraax@upmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed THINKERS-X: Lung, the eXtended multimodal evolution of THINKERS-Lung, to determine whether multisequence MRI radiomics provides incremental value for lesion-specific outcome prediction and exploratory dose-scenario evaluation after Gamma Knife radiosurgery (GKRS) for lung cancer brain metastases. We performed a retrospective single-center study of 767 patients with 3,728 lung cancer brain metastases treated with GKRS. THINKERS-X preserved the original mixture-of-experts and discrete-time survival architecture while adding a dedicated computational neuroradiology expert. Approximately 2,400 radiomic features per metastasis were extracted from pretreatment FSPGR/T1-weighted postcontrast, T2-weighted, and SWAN MRI. Validation used patient-grouped 5-fold cross-validation and a completely closed patient-grouped internal holdout cohort. In grouped cross-validation, THINKERS-X achieved a mean AUC

Indexed as

Brain NeoplasmsLung NeoplasmsMagnetic Resonance ImagingRadiosurgeryAgedFemaleHumansMaleMiddle AgedPrognosisRadiomicsRetrospective StudiesTreatment OutcomeArtificial intelligenceLung brain metastasesMixture of expertsRadiomicsStereotactic radiosurgery

Identifiers

PMID42891725

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.