Evidence map›Paper›PMID 42891566›Full record

ArticleTransboundary and emerging diseases2026

Immune Responsiveness Induced by Administration of Heat-Inactivated M. bovis and BCG Prior to Experimental Infection in African Buffalo.

J M Hewlett, L M de Klerk Lorist, E P Mitchell, L J Nupen, I A Sevilla, C Gortazar, V P M G Rutten, R Juste, A L Michel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J M HewlettDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Gauteng P/Bag X04, Pretoria, 0110, South Africa, up.ac.za.ORCID https://orcid.org/0000-0002-6257-585X
L M de Klerk LoristDepartment of Agriculture, Land Reform and Rural Development, Skukuza, South Africa.ORCID https://orcid.org/0000-0001-7348-3910
E P MitchellCentre: Veterinary Wildlife Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa, up.ac.za.ORCID https://orcid.org/0000-0003-0379-3790
L J NupenDepartment of Zoology and Entomology, University of Pretoria, Pretoria, South Africa, up.ac.za.ORCID https://orcid.org/0000-0003-1030-6057
I A SevillaDepartment of Animal Health, Neiker, Derio, Bizkaia, Spain.ORCID https://orcid.org/0000-0003-3968-3390
C GortazarSaBio Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC, JCCM, Universidad de Castilla La Mancha, Ciudad Real, Spain, uclm.es.ORCID https://orcid.org/0000-0003-0012-4006
V P M G RuttenDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Gauteng P/Bag X04, Pretoria, 0110, South Africa, up.ac.za.ORCID https://orcid.org/0000-0002-6171-1805
R JusteDepartment of Animal Health, Neiker, Derio, Bizkaia, Spain.ORCID https://orcid.org/0000-0001-6037-5873
A L MichelDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Gauteng P/Bag X04, Pretoria, 0110, South Africa, up.ac.za.ORCID https://orcid.org/0000-0001-9240-2653

Funding

AfriVet BimedaAgriSETABelgian Directorate-General for Development Cooperation (DGD)DGD-ITM Framework Agreement 4University of PretoriaWildlife Group of the South African Veterinary Association
6 · The paper itself

Abstract

African buffalo (Syncerus caffer) are the primary wildlife reservoir for bovine tuberculosis (BTB) in Africa. Infected buffalo populations spread BTB to numerous species in conservation areas as well as to cattle at park boundaries. Quarantine requirements for BTB complicate wild animal metapopulation management. Considerable interest has arisen in the vaccination of cattle and indigenous wildlife species against BTB as an additional control strategy. This pilot trial aimed to evaluate cell-mediated and humoral immune responses in African buffalo immunised against BTB. Twenty-one sub-adult African buffalo were divided into four treatment groups, and received either Bacillus Calmette-Guérin (BCG; 10

Indexed as

BCG VaccineBuffaloesMycobacterium bovisTuberculosisTuberculosis, BovineAnimalsCattlePilot ProjectsVaccines, InactivatedBCG VaccineVaccines, InactivatedAfrican buffaloantibody responseBCGbovine tuberculosisheat-inactivatedimmunisationinterferon-gamma release assayintra-dermal tuberculin testMycobacterium bovisSyncerus caffer

Identifiers

PMID42891566
PMCPMC13675938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.