ArticleJournal of diabetes science and technology2026
Timing of Insulin Glargine Administration During Intermittent Ramadan Fasting in patients With Type1 Diabetes: A Randomized Controlled Trial (GLARIF).
Article in Journal of diabetes science and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04383990 (Comparison of Early Versus Late Administration of Insulin Glargine in Patients With type1 Diabetes During Fasting Ramadan), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Comparison of Early Versus Late Administration of Insulin Glargine in Patients With type1 Diabetes During Fasting Ramadan
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe effect of basal insulin timing on hypoglycemia during Ramadan fasting remains uncertain despite recommendations to administer basal insulin earlier in the evening. We evaluated whether early evening compared with bedtime administration of insulin glargine reduces hypoglycemia and improves glycemic outcomes in individuals with type1 diabetes (T1D) fasting during Ramadan.
methodsThis multicenter open-label randomized controlled trial was conducted across 4 centers in Saudi Arabia. Participants with T1D intending to fast Ramadan were randomized to early evening or bedtime glargine administration. Glucose data were collected using self-monitoring of blood glucose (SMBG), intermittently scanned continuous glucose monitoring (FreeStyle Libre), and blinded continuous glucose monitoring (CGM; Medtronic iPro2).
resultsA total of 185 participants were analyzed (91 early evening, 94 bedtime). Baseline characteristics were similar between groups. Fasting interruption occurred in 75.9% versus 76.3% of participants (
conclusionChanging insulin glargine administration from bedtime to earlier evening hours during Ramadan fasting did not significantly reduce hypoglycemia or improve overall glucose profiles in individuals with T1D. These findings suggest that routine universal shifting of basal insulin timing during Ramadan may not be necessary and support an individualized approach based on patient preference and glucose patterns. CLINICALTRIALS: gov identifier: NCT04383990.
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