Evidence map›Paper›PMID 42891438›Full record

ArticleDrugs in context2026

Biochemical and clinical changes during enzymatic replacement therapy in hypophosphatasia: three real-world cases in Spain.

Mercedes Marbán Calzón, María Pilar Aguado Acín, Juan Luis Carrillo-Linares, Alicia González Jimeno, José Rioja Villodres, Carolina Tornero Marín

Abstract read
In one paragraph

Article in Drugs in context, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mercedes Marbán CalzónServicio de Pediatría, Unidad de Endocrinología, Hospital General Mancha Centro, Alcázar de San Juan, Ciudad Real, Spain.
María Pilar Aguado AcínServicio de Reumatología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
Juan Luis Carrillo-LinaresLipid and HTN-Vascular Risk Unit, Internal Medicine Service, Virgen de la Victoria University Hospital, Málaga, Spain.ORCID https://orcid.org/0000-0003-0968-3234
Alicia González JimenoServicio de Pediatría, Unidad de Endocrinología, Hospital General Mancha Centro, Alcázar de San Juan, Ciudad Real, Spain.
José Rioja VillodresIBIMA Plataforma BIONAND, Instituto de Investigación Biomédica de Málaga, Málaga, Spain.ORCID https://orcid.org/0000-0002-1196-0352
Carolina Tornero MarínServicio de Reumatología, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.ORCID https://orcid.org/0000-0001-8484-3475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypophosphatasia (HPP) is a rare recessive or dominant autosomal disease caused by loss-of-function variants in the

Indexed as

alkaline phosphatasehypophosphatasiainorganic pyrophosphatephosphoethanolaminepyridoxal-5′-phosphatetissue-nonspecific alkaline phosphatase

Identifiers

PMID42891438
PMCPMC13674974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.