Evidence map›Paper›PMID 42891410›Full record

ArticleCrystal growth & design2026

Crystallization for Manufacturing in Microgravity; Are We There Yet?

Maria Del Carme Pons Royo, Erin Howard, Giovanni Aprile, Bria Morse, Anna Wadhwa, Jayna Wadhwa, Rodolfo J Romañach, Gerardo Morell, Richard D Braatz, Lonnie Petersen and 1 more

Abstract read
In one paragraph

Article in Crystal growth & design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Del Carme Pons RoyoDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, United States.
Erin HowardDepartment of Mathematics and Department of Political Science, Wellesley College, Wellesley, Massachusetts 02481, United States.
Giovanni AprileDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, United States.ORCID 0000-0001-6549-3107
Bria MorseDepartment of Aeronautics & Astronautics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Anna WadhwaDepartment of Aeronautics & Astronautics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Jayna WadhwaDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Rodolfo J RomañachDepartment of Chemistry, University of Puerto Rico, Mayagüez, Puerto Rico 00681, United States.ORCID 0000-0001-7513-7261
Gerardo MorellDepartment of Physics, University of Puerto Rico, San Juan, Puerto Rico 00931, United States.
Richard D BraatzDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, United States.ORCID 0000-0003-4304-3484
Lonnie PetersenDepartment of Aeronautics & Astronautics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Torsten StelzerDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, United States; Department of Pharmaceutical Sciences, University of Puerto Rico, San Juan, Puerto Rico 00936, United States; Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan, Puerto Rico 00926, United States.ORCID 0000-0003-3881-0183

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

Crystallization in microgravity has been extensively investigated because of its potential to enhance crystal quality compared to terrestrial conditions. While early efforts were primarily directed toward single-crystal growth for structural studies, increasing attention is now being given to its relevance for manufacturing in low-Earth orbit (LEO) and future in-space manufacturing (ISM). This review provides a structured and systematic analysis of the literature on microgravity crystallization by examining the materials studied, distinguishing between single-crystal and bulk crystal regimes, and evaluating the experimental methodologies used to investigate crystallization kinetics. Emphasis is placed on the current platforms. By adopting a manufacturing perspective, this work identifies key challenges and outlines directions for advancing microgravity crystallization toward scalable and controlled processes for manufacturing under microgravity. To date, the current body of literature remains fragmented and insufficiently aligned with process engineering and manufacturing considerations, including restricted in situ monitoring, a lack of standardization, and limited comparability across studies.

Identifiers

PMID42891410
PMCPMC13674690

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.