ArticleRSC advances2026
Batch sequential production of medicated Janus fibrous films of polyvinylpyrrolidone/shellac for treating pharyngitis.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
Janus structures are highly popular for developing functional materials, including drug delivery systems, whereas batch production of Janus fibrous films represents one of the most difficult challenges. Here, based on a brand-new integrated multi-orifice spinneret, Janus fibrous films were fabricated directly through a sequential batch electrospinning process. The films contained a top layer of polyvinylpyrrolidone (PVP), borneol, sucralose, and acetaminophen (APAP) for rapid drug release, and a bottom layer of shellac, PVP, borneol, sucralose, and APAP for sustained drug release. Scanning electron microscopy results verified that both the top and bottom layers were composed of ultra-thin linear fibers without beads or spindles. X-ray diffraction and Fourier-transform infrared spectroscopy results verified that borneol and APAP were present in the Janus films in an amorphous state and exhibited good compatibility with the polymeric matrices. The Janus fibrous films can be cut into small patches for topical administration to treat pharyngitis. Artificial tongue and saliva models were exploited to conduct
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