Evidence map›Paper›PMID 42891387›Full record

ReviewJournal of hepatocellular carcinoma2026

Knowledge Mapping and Frontier Evolution of Traditional Medicine in Hepatocellular Carcinoma Research: A Bibliometric Analysis.

Ling Cai, Gang Wang, Tao Yang, Honglin Luo

Abstract readReview
In one paragraph

Review in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ling Cai *School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning, 530008, People's Republic of China.ORCID 0009-0008-6919-5535
Gang Wang *Basic Medical Research Center, Guangxi Academy of Medical Sciences, Nanning, Guangxi, 530021, People's Republic of China.
Tao YangBasic Medical Research Center, Guangxi Academy of Medical Sciences, Nanning, Guangxi, 530021, People's Republic of China.
Honglin LuoBasic Medical Research Center, Guangxi Academy of Medical Sciences, Nanning, Guangxi, 530021, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Existing treatments are limited by high recurrence rates and drug resistance. Traditional medicine have the potential to be used to treat HCC because of their multi-target and low toxicity properties, however, there is no general review of the state of studies and tendencies. According to Web of Science Core Collection (WoSCC), this paper has analyzed 1936 English articles and reviews through bibliometric analysis of the data with CiteSpace and Bibliometrix, including publication trends, country/region distribution, the occurrence of keywords, collaboration networks, thematic evolution. The output of literature has been growing exponentially since 2020. The main contributor is China, which plays a central role in international cooperation. An important partner is the United States, and Egypt and France are possible partners. The area of interest is active ingredients, apoptosis modulation, and networking pharmacology. Network pharmacology and molecular docking are fundamental technologies. Emerging frontiers are tumor microenvironment, gut microbiota, lipid metabolism, and NF-κB signaling pathway. NF-κB activation, apoptosis, and angiogenesis regulation are new hotspots. This study systematically elucidates the research status and future directions of traditional medicine in the treatment of HCC, providing a reference for the prevention and treatment of HCC with traditional medicine. However, this study exclusively selected the WoSCC database for analysis, which may have the limitation of not comprehensively covering all research achievements relevant to this field.

Indexed as

bibliometric analysishepatocellular carcinomatraditional medicinetumor microenvironment

Identifiers

PMID42891387
PMCPMC13674563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.