Evidence map›Paper›PMID 42891339›Full record

ReviewiMetaOmics2026

Microbiome-pancreatic cancer crosstalk: From tumor biology to therapeutic intervention.

Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B Hylemon and 3 more

Abstract readReview
In one paragraph

Review in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuqin XieSchool of Medicine, Chongqing University Chongqing University Cancer Hospital Chongqing China.ORCID https://orcid.org/0009-0003-2937-7477
Jingyuan YeDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.
Sheng WangDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.
Maoyun LiuDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.
Fengsheng DaiDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.ORCID https://orcid.org/0000-0002-4202-9173
Mingzhen BaiDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.
Yi WangDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.
Athena SavojiDepartment of Chemical and Physical Sciences University of Toronto Mississauga Toronto Ontario Canada.
Yu WangDepartment of Hepatobiliary Pancreatic Tumor Center, Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis Chongqing University Cancer Hospital Chongqing China.
Phillip B HylemonDepartment of Microbiology and Immunology Virginia Commonwealth University Richmond Virginia USA.
Huiping ZhouDepartment of Microbiology and Immunology Virginia Commonwealth University Richmond Virginia USA.
Hui LiSchool of Medicine, Chongqing University Chongqing University Cancer Hospital Chongqing China.
Dewei LiSchool of Medicine, Chongqing University Chongqing University Cancer Hospital Chongqing China.

Funding

BLRD VA IK6 BX004477
6 · The paper itself

Abstract

Pancreatic cancer (PC) remains one of the most lethal malignancies worldwide, characterized by dense desmoplastic stroma, profound immunosuppression, and poor responsiveness to conventional therapies. Accumulating evidence positions the intratumoral microbiome, encompassing bacteria as well as understudied fungal and viral components, as a critical regulator of PC pathogenesis, tumor microenvironment (TME) remodeling, and therapeutic efficacy. In this review, we synthesize the current understanding of the pancreatic intratumoral microbiome, including its distinct composition relative to normal pancreatic tissue, gut microbiota, and oral microbiota. The PC intratumoral microbiome is characterized by enrichment of validated pro-tumorigenic drivers (e.g.,

Indexed as

biomarkersimmune suppressionintratumoral microbiomemetabolic reprogrammingmicrobiota‐targeted therapypancreatic cancertumor microenvironment

Identifiers

PMID42891339
PMCPMC13674442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.