ArticleiMetaOmics2026
Resistome flow in global landfill systems.
Article in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Antibiotic resistance genes (ARGs) represent a critical global public health threat. Effective resistome management within the One Health framework requires a comprehensive understanding of the sources and movement of ARGs across environmental media. This study provides a detailed analysis of resistome characteristics and dynamics in global landfill systems. Landfill systems were found to harbor diverse and highly mobile ARGs, with multidrug-resistant genes (MDRGs) comprising 32.63% of total ARGs, and comparable or even higher levels of associated ARG subtypes than in other environmental media, such as acidic mine wastewater. The ARG density on plasmids was 3.5 times higher than that on chromosomal sequences, with five times more abundant ARG-carrying plasmid-associated contigs in landfill systems than that in wastewater. At the metagenome-assembled genome level, members of the phylum Pseudomonadota were identified as the most abundant hosts (29.72%), harboring 47.74% and 56.47% of the total ARGs and MDRGs, respectively. Genomic analysis of 35
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