Evidence map›Paper›PMID 42891326›Full record

ReviewiMetaOmics2026

Harnessing microbial metabolism and nutrition to target the gut-mammary axis for better livestock production and health.

Aolong Zhou, Cheng Guo, Mahmoud M Abdelsattar, Ahmad R Musa, Mequanint Biks, Abdullahi A Musa, Shahnaz Rahman, Abera Teshome Aleli, Pei Zhong, Jiawei Zhang and 20 more

Abstract readReview
In one paragraph

Review in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Aolong ZhouCollege of Animal Science and Technology Ningxia University Yinchuan China.ORCID https://orcid.org/0009-0008-8458-5013
Cheng GuoCollege of Animal Science and Technology Ningxia University Yinchuan China.ORCID https://orcid.org/0000-0003-3770-0804
Mahmoud M AbdelsattarKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.ORCID https://orcid.org/0000-0002-1650-3062
Ahmad R MusaKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Mequanint BiksKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.ORCID https://orcid.org/0000-0002-2976-478X
Abdullahi A MusaKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Shahnaz RahmanKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Abera Teshome AleliKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Pei ZhongKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Jiawei ZhangKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Junwei CuiCollege of Animal Science and Technology Ningxia University Yinchuan China.ORCID https://orcid.org/0009-0002-8201-6999
Xiyan KouKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Qingyuan YuKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Caijuan YueInstitute of Animal Science Ningxia Academy of Agricultural and Forestry Sciences Yinchuan China.ORCID https://orcid.org/0000-0002-1380-1160
Qin LiKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Dan ZhangKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Zixuan PengCollege of Animal Science and Technology Ningxia University Yinchuan China.
Ao RenKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Ziqi TianKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Ziqi LiuKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Yaona ZhangKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Lili ZhangCollege of Animal Science and Technology Ningxia University Yinchuan China.
Dina KarmallahKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Naifeng ZhangKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Tao MaKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.ORCID https://orcid.org/0000-0003-4821-836X
Yan TuKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.ORCID https://orcid.org/0000-0002-4324-6188
Qiyu DiaoKey Laboratory of Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research Chinese Academy of Agricultural Sciences Beijing China.
Guijie ZhangCollege of Animal Science and Technology Ningxia University Yinchuan China.
Xiaofeng XuCollege of Animal Science and Technology Ningxia University Yinchuan China.
Yanliang BiCollege of Animal Science and Technology Ningxia University Yinchuan China.ORCID https://orcid.org/0000-0001-8183-8208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut-mammary axis orchestrates bidirectional crosstalk linking intestinal homeostasis and mammary function through integrated neural, endocrine, and immune pathways. Dysregulation driven by gut microbiota dysbiosis or metabolic dysfunction compromises lactation performance and induces mastitis via pathogen translocation and epigenetic reprogramming. This review systematically discusses the molecular mechanisms underlying microbial metabolite-mediated mammary development and lactation efficiency, evaluates the impact of gut-derived pathogens on mammary barrier integrity and inflammatory cascades, explores maternal offspring microbiome transmission for neonatal immunity programming, and proposes precise nutritional strategies targeting microbial immune metabolic networks. Our synthesis of previous research findings aimed to optimize animal productivity, prevent mammary gland disorders, and provide insights for the advancement of the livestock industry.

Indexed as

gut–mammary axisgut microbiotamammary healthmaternal‐offspring transmissionprecision nutrition

Identifiers

PMID42891326
PMCPMC13674412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.