Evidence map›Paper›PMID 42891321›Full record

ArticleiMetaOmics2026

Ginseng polysaccharides prevent mastitis through

Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhijie ZhengMOA Key Laboratory of Animal Virology Zhejiang University Center for Veterinary Sciences Hangzhou China.
Huiying LiuKey Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China.
Sizhe ChenMicrobiota I-Center (MagIC) Hong Kong China.ORCID https://orcid.org/0009-0008-0937-4873
Jianhui GuState Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology (IGDB) Chinese Academy of Sciences Beijing China.
Sisi CaiMOA Key Laboratory of Animal Virology Zhejiang University Center for Veterinary Sciences Hangzhou China.
Xiang LiuMOA Key Laboratory of Animal Virology Zhejiang University Center for Veterinary Sciences Hangzhou China.
Raphaela I LauMicrobiota I-Center (MagIC) Hong Kong China.
Yao ZhangDepartment of Gastroenterology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China.
Sunjae LeeSchool of Life Sciences Gwangju Institute of Science and Technology Gwangju Republic of Korea.
Xiaoyan WangMOA Key Laboratory of Animal Virology Zhejiang University Center for Veterinary Sciences Hangzhou China.
Kewei FanFujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology College of Life Sciences, Longyan University Longyan China.
Xiaole YinSchool of Civil and Environmental Engineering Nanyang Technological University Singapore Singapore.
Hein Min TunMicrobiota I-Center (MagIC) Hong Kong China.ORCID https://orcid.org/0000-0001-7597-5062
Renyou GanLi Ka Shing Institute of Health Sciences, Faculty of Medicine The Chinese University of Hong Kong Hong Kong China.ORCID https://orcid.org/0000-0002-4162-1511
Haichong WuMOA Key Laboratory of Animal Virology Zhejiang University Center for Veterinary Sciences Hangzhou China.ORCID https://orcid.org/0000-0001-8190-0040
Qi SuMicrobiota I-Center (MagIC) Hong Kong China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mastitis, a common inflammatory disease of breast tissue, has been linked to gut microbiota dysbiosis; however, evidence establishing a causal relationship and the potential for microbiome-based therapies remains limited. This study investigated the gut-mammary gland axis and how the prebiotic candidate ginseng polysaccharide (GP) prevents mastitis. Using Lipopolysaccharide (LPS)-induced mouse models, we demonstrate that mastitis involves gut dysbiosis contributing to pathogenesis. GP prevented mastitis in a microbiota-dependent manner. Mechanistically, GP selectively enriches

Indexed as

deoxycholic acidginseng polysaccharidesLactobacillus murinusLPS‐induced mastitismicrobiota‐derived metabolites

Identifiers

PMID42891321
PMCPMC13674426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.