Evidence map›Paper›PMID 42891305›Full record

ArticleiMetaOmics2026

Gene expression signatures from single-cell transcriptomics predict Sjögren's syndrome.

Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo and 11 more

Abstract read
In one paragraph

Article in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shumin ChengThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.ORCID https://orcid.org/0009-0000-2533-4769
Ling YanThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Yilin WuShenzhen University of Advanced Technology General Hospital Shenzhen China.
Yan LiThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Ziheng YeThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Zhen ZhangShenshan Medical Center, Sun Yat-sen Memorial Hospital Sun Yat-Sen University Shanwei China.
Yi ZhangThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Jingyun MaThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Yuhong LiangSchool of Pharmacy Macau University of Science and Technology Macau China.
Zhaofan LuoThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Huacheng WangThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Meili GaoThe Second People's Hospital of Futian District Shenzhen China.
Chao QinThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Ke ZhuThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Yun LengThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Kamran UllahDepartment of Biology The University of Haripur Haripur KP Pakistan.
Jun LiangThe Seventh Affiliated Hospital Sun Yat-sen University Shenzhen China.
Haiyan YanShenshan Medical Center, Sun Yat-sen Memorial Hospital Sun Yat-Sen University Shanwei China.
Guan YangDepartment of Infectious Diseases and Public Health City University of Hong Kong Hong Kong China.
Yingqian MoShenshan Medical Center, Sun Yat-sen Memorial Hospital Sun Yat-Sen University Shanwei China.
Bihui HuangShenshan Medical Center, Sun Yat-sen Memorial Hospital Sun Yat-Sen University Shanwei China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sjögren's syndrome (SjS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to dry eyes and mouth. While previous genome-wide association studies (GWAS) and transcriptomic analyses have identified genes associated with SjS, predictive models based on single-cell resolution are limited. In this study, single-cell RNA sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) of SjS patients were analyzed to map immune cell alterations linked to the disease. Compared with healthy controls, SjS patients displayed decreased proportions of naïve

Indexed as

immune landscapepredictive signaturesingle‐cell RNA sequencingSjögren's syndrome

Identifiers

PMID42891305
PMCPMC13674423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.