ArticleInternational journal of chronic obstructive pulmonary disease2026
Global, Regional, and National Burden of Chronic Obstructive Pulmonary Disease-Associated Heart Failure: A Systematic Analysis of the Global Burden of Disease Study from 1990 to 2021 with Projections up to 2050.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is strongly linked to heart failure (HF), but comprehensive global evaluations of COPD-associated HF remain limited. Methods: Using Global Burden of Disease Study 2021 data, we assessed prevalence and years lived with disability (YLDs) of COPD-associated HF. We applied decomposition analysis, Joinpoint regression, and Bayesian age-period-cohort modeling to evaluate trends by sex, age, sociodemographic index (SDI), and region, and to project burden to 2050. Results: In 2021, global COPD-associated HF cases exceeded 3.61 million, a 1.4-fold increase since 1990. Age-standardized prevalence rates (ASPR) and YLD rates (ASYR) increased overall. Absolute cases and YLDs rose in both sexes, but age-standardized rates declined in males and rose in females. Burden peaked at ages 70-74 and grew fastest among those aged ≥95. The Middle SDI region had the highest counts; East Asia had the highest regional burden, and China the highest national absolute burden. Only High-SDI regions showed rising ASPR and ASYR; most other regions declined, notably Eastern Europe. Projections indicate global increases in ASPR and ASYR from 2022 to 2050, with slightly higher rises in females than males. Conclusion: The global burden of COPD-associated HF continues to rise with substantial heterogeneity and is projected to increase further. Coordinated international efforts and targeted prevention and management are urgently needed.
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