Evidence map›Paper›PMID 42891226›Full record

ArticleNpj gut and liver2025

Automated digital analysis of propagated contractions recorded during fasting using high resolution small intestinal manometry in healthy participants.

Poulami Samaddar, Luis Gerardo Alcala Gonzalez, Jeffrey Fetzer, Irene Cofrades Del Castillo, Shivaram Poigai Arunachalam, Fernando Azpiroz, Michael Camilleri, Arthur Beyder, Carolina Malagelada

Abstract read
In one paragraph

Article in Npj gut and liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Poulami SamaddarEnteric NeuroScience Program (ENSP), Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Luis Gerardo Alcala GonzalezDigestive System Research Unit, University Hospital Vall d'Hebron; Universitat Autonoma de Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.
Jeffrey FetzerDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Irene Cofrades Del CastilloDigestive System Research Unit, University Hospital Vall d'Hebron; Universitat Autonoma de Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.
Shivaram Poigai ArunachalamDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Fernando AzpirozDigestive System Research Unit, University Hospital Vall d'Hebron; Universitat Autonoma de Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.
Michael CamilleriDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Arthur BeyderEnteric NeuroScience Program (ENSP), Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN, USA.
Carolina MalageladaDigestive System Research Unit, University Hospital Vall d'Hebron; Universitat Autonoma de Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.

Funding

MECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLSR01DK052766 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR, FARRUGIA, GIANRICO · 1997 to 2025
$8.3M
Mechanotransduction in gastrointestinal physiologyR01DK123549 · NIDDK · MAYO CLINIC ROCHESTER · PI Arthur Beyder · 2019 to 2026
$3.7M
Defining and modeling the cellular interactions for rhythmic colon motilityR01DK136906 · NIDDK · MAYO CLINIC ROCHESTER · PI Kristen Michelle Smith-Edwards · 2023 to 2026
$2.6M
Does the gut have a sense of touch?DP2AT010875 · NCCIH · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2019 to 2019
$2.4M
NCCIH NIH HHS DP2 AT010875NIDDK NIH HHS R01 DK052766NIDDK NIH HHS R01 DK123549NIDDK NIH HHS R01 DK136906
6 · The paper itself

Abstract

Manometry, the gold standard for evaluating phasic contractions in the alimentary tract, relies heavily on qualitative pattern recognition, despite generating large volumes of data. Our aim was to develop an automated detection tool that can quantify fundamental manometric events in high-resolution small bowel manometry tracings by assessing their parameters. Digitally identified propagated contractile events (PCEs) are compared to manual analysis; the system achieved 86% accuracy and 91% precision. Utilizing this automated system, we analyzed approximately 30 h of manometry recordings gathered from 10 healthy subjects. The velocity of fully propagated PCEs is significantly faster, and there was a significant decrease in the frequency of the PCEs following phase III activity. We conclude that computer vision-based automated evaluation of PCEs may improve our understanding of fasting intestinal motility in both health and disease.

Identifiers

PMID42891226
PMCPMC13673980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.