Evidence map›Paper›PMID 42891173›Full record

ArticleFrontiers in microbiology2026

Untargeted metabolomics reveals distinct metabolic profiles and putative bioactive metabolites in cell-free supernatants of food-grade microorganisms.

Denise Drago, Luca Marini, Eleonora Bafile, Federica Federici, Radmila Pavlovic, Marynka Ulaszewska, Gianfranco Frigerio, Laura Manna, Annapaola Andolfo

Abstract read
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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Denise DragoProteomics and Metabolomics Facility (ProMeFa), Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Luca MariniNTP Biotech S.r.l., Teramo, Italy.
Eleonora BafilePNK Farmaceutici S.p.A., Teramo, Italy.
Federica FedericiPNK Farmaceutici S.p.A., Teramo, Italy.
Radmila PavlovicProteomics and Metabolomics Facility (ProMeFa), Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marynka UlaszewskaProteomics and Metabolomics Facility (ProMeFa), Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Gianfranco FrigerioProteomics and Metabolomics Facility (ProMeFa), Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Laura Manna *PNK Farmaceutici S.p.A., Teramo, Italy.
Annapaola Andolfo *Proteomics and Metabolomics Facility (ProMeFa), Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decade, the understanding of the role of microorganisms in health and disease has expanded considerably, with many of the beneficial effects traditionally attributed to probiotics now also being associated with their metabolites, collectively referred to as postbiotics. In this context, postbiotics are increasingly being explored as complementary components of broader microbiome-centered strategies. Fermentation supernatants are commonly regarded as industrial by-products; however, they contain a diverse repertoire of microbially derived metabolites with potential biological relevance. The valorization of these fermentation streams therefore represents a promising strategy for identifying novel compounds capable of modulating host physiology. Five food-grade microorganisms-

Indexed as

by-product wasteindustrial fermentationpostbioticsprobioticsuntargeted metabolomics

Identifiers

PMID42891173
PMCPMC13673657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.