Evidence map›Paper›PMID 42891161›Full record

ArticleRSC chemical biology2026

ARCaDia-selected short DNA core positions a latent warhead for protein-gated covalent capture.

Chaohui Li, Naoyuki Miyashita, Masayasu Kuwahara, Jay Yang, Masumi Taki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chaohui LiDepartment of Engineering Science, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu Tokyo 182-8585 Japan jyang75@wisc.edu taki@pc.uec.ac.jp +81-42-443-5980.ORCID https://orcid.org/0009-0004-4226-2559
Naoyuki MiyashitaDepartment of Engineering Science, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu Tokyo 182-8585 Japan jyang75@wisc.edu taki@pc.uec.ac.jp +81-42-443-5980.
Masayasu KuwaharaGraduate School of Integrated Basic Sciences, Nihon University, Setagaya-ku Tokyo 156-8550 Japan.ORCID https://orcid.org/0000-0002-0810-4627
Jay YangDepartment of Engineering Science, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu Tokyo 182-8585 Japan jyang75@wisc.edu taki@pc.uec.ac.jp +81-42-443-5980.
Masumi TakiDepartment of Engineering Science, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu Tokyo 182-8585 Japan jyang75@wisc.edu taki@pc.uec.ac.jp +81-42-443-5980.ORCID https://orcid.org/0000-0002-1811-8029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A single-round affinity/reactivity co-selection of aptamer (ARCaDia), combined with Fast String-Based Clustering (FSBC) analysis of the selection output, identified a compact 10-nucleotide DNA-warhead core motif for streptavidin-selective covalent capture, showing that protein-gated covalent chemistry can arise from a short sequence-dependent placement of a latent warhead in a biotin-sensitive reaction microenvironment. This demonstrates that functional warhead-positioning information is already present after a single selection round.

Identifiers

PMID42891161
PMCPMC13673413

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.