Evidence map›Paper›PMID 42891147›Full record

ArticleExtracellular vesicles and circulating nucleic acids2026

Region-specific human cardiac extracellular vesicles differentially regulate mitochondrial function.

Genevieve C Sparagna, Christina M Coughlan, Hailey L Chapman, Sydney R Shuff, Ashley E Pietra, Benjamin J Kopecky, Alicia J Chapman, Eva M Medina, Anthony J Saviola, Kathryn C Chatfield and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Extracellular vesicles and circulating nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Genevieve C SparagnaDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Christina M CoughlanDepartment of Neurology, University of Colorado Anschutz, Aurora, CO 80045, USA.
Hailey L ChapmanDepartment of Life Sciences, Division of Systems and Synthetic Biology, Chalmers University of Technology, Gothenburg 41296, Sweden.
Sydney R ShuffDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ashley E PietraDepartment of Pediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO 80045, USA.
Benjamin J KopeckyDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Alicia J ChapmanDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Eva M MedinaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Anthony J SaviolaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kathryn C ChatfieldDepartment of Pediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO 80045, USA.
Shelley D MiyamotoDepartment of Pediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO 80045, USA.
Anastacia M GarciaDepartment of Pediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO 80045, USA.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Glycosphingolipid-Mediated Cardiomyocyte and Immune Cell Dysfunction in Hypoplastic Left Heart SyndromeR01HL171600 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Anastacia M Garcia · 2024 to 2026
$1.7M
A Novel Probiotic Drug Delivery Platform for Oral Administration of Protein-Based TherapiesR43TR004300 · NCATS · RISE THERAPEUTICS, LLC · PI FURLAN FREGUIA, CHRISTIAN · 2022 to 2022
$283k
NCATS NIH HHS R43 TR004300NHLBI NIH HHS R01 HL171600NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiolipininterfibrillarliquid chromatography mass spectrometrymitochondriaphospholipidsproteomicsseahorsesubsarcolemmal

Identifiers

PMID42891147
PMCPMC13673452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.