Evidence map›Paper›PMID 42891130›Full record

ArticleJournal of molecular and cellular cardiology plus2026

Absence of arrhythmogenic effects in cAMP subcellular compartments supports PDE8 as a target in atrial fibrillation.

David Revuelta, Nefeli Grammatika Pavlidou, Cristina Aceituno, Issam Abu Taha, Andrea Brunetti, Antonino Ginel, Evaldas Girdauskas, Dobromir Dobrev, Leif Hove-Madsen, Cristina E Molina

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David RevueltaInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg -Eppendorf (UKE), Hamburg, Germany.
Nefeli Grammatika PavlidouInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg -Eppendorf (UKE), Hamburg, Germany.
Cristina AceitunoBiomedical Research Institute Barcelona (IIBB-CSIC) and Institut de Recerca Sant Pau (IR Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Issam Abu TahaInstitute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
Andrea BrunettiInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg -Eppendorf (UKE), Hamburg, Germany.
Antonino GinelCardiac Surgery Department and IR Sant Pau, St. Antoni Mª Claret 167, 08025, Barcelona, Spain.
Evaldas GirdauskasDZHK (German Centre for Cardiovascular Research), partner site North, Germany.
Dobromir DobrevInstitute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
Leif Hove-MadsenBiomedical Research Institute Barcelona (IIBB-CSIC) and Institut de Recerca Sant Pau (IR Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Cristina E MolinaInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg -Eppendorf (UKE), Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Targeting Phosphodiesterase 8B (PDE8B) has been proposed as a strategy to restore L-type Ca Objective: The aim of this study was to assess whether PDE8 contributes to the regulation of cAMP signaling in other Ca Results: Fluorescence resonance energy transfer (FRET) live-cell imaging, confocal Ca Conclusion: These results suggest that PDE8 inhibition promotes a compartment-specific regulation of cAMP signaling that exclusively affects the L-type Ca

Indexed as

Atrial fibrillationCa2+ handlingcAMPHuman atriaPDE8

Identifiers

PMID42891130
PMCPMC13673357

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.