Evidence map›Paper›PMID 42891122›Full record

ArticleOphthalmology science2026

Age-Related Hypofluorescent Indocyanine Green Angiography Spots: Prevalence, Characteristics, and Associated Features in Age-Related Macular Degeneration.

Chui Ming Gemmy Cheung, Zehua Jiang, Noa Gilead, Wataru Kikushima, Christine A Curcio, Kelvin Yi Chong Teo

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Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chui Ming Gemmy CheungMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Zehua JiangMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Noa GileadMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Wataru KikushimaMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Christine A CurcioDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
Kelvin Yi Chong TeoMedical Retina Department, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the frequency and associated features of detecting age-related scattered hypofluorescent spots (ASHS) on indocyanine green angiography (ICGA) among fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD). Design: Imaging analysis. Participants: Prospectively recruited cohort with treatment-naive nAMD. Methods: Patients underwent protocolized examination. Indocyanine green angiography was used to evaluate the presence of ASHS. Choriocapillaris vessel density was determined using OCT angiography (OCTA). The development of incident exudative age-related macular degeneration over 12 months was recorded. Main Outcome Measures: Prevalence and associated features of ASHS. Results: We included 142 patients. Macular neovascularization (MNV)-subtype in the fellow eye was polypoidal choroidal vasculopathy (PCV; 60.5%), type I/mixed MNV (26.1%), type II (9.9%), and type III (3.5%). According to ICGA, eyes were categorized into homogeneous ( Conclusions: One in 3 fellow eyes of patients with unilateral nAMD in this Asian population exhibited ASHS lesions. Choriocapillaris vessel density based on OCTA was similar between the ASHS and the homogeneous groups, supporting the hypothesis for reduced transit of indocyanine green-laden lipoproteins across the Bruch membrane. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Age-related macular degenerationAge-related scattered hypofluorescent spotsIndocyanine green angiographyLipidPolypoidal choroidal vasculopathy

Identifiers

PMID42891122
PMCPMC13673339

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