Evidence map›Paper›PMID 42891109›Full record

ArticleJAC-antimicrobial resistance2026

Emergence and dissemination of an IncC plasmid co-harbouring

Roberto Sierra, Betsy Castro, Elsa De La Cadena, Laura J Rojas, Juan Carlos García-Betancur, Mélanie Roch, Steven M Marshall, Nalleth Bolaño-Ardila, Susan D Rudin, Janneth J Escobar-Arcos and 6 more

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Article in JAC-antimicrobial resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Roberto SierraDivision of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-8657-1781
Betsy CastroGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá, Colombia.
Elsa De La CadenaGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá, Colombia.
Laura J RojasDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, OH, USA.
Juan Carlos García-BetancurGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá, Colombia.
Mélanie RochDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-6485-8434
Steven M MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Nalleth Bolaño-ArdilaDepartamento de Microbiología, Universidad Popular del Cesar, Valledupar, Cesar, Colombia.
Susan D RudinResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Janneth J Escobar-ArcosLaboratorio Clínico, Clínica Imbanaco, Grupo Quirónsalud, Cali, Colombia.
Clara J Salazar-MontesLaboratorio de Microbiología, Clínica Nuestra Cali, Cali, Colombia.
Belkis Palacio-VillalbaFatoxacol SAS. Departamento de Investigación, Grupo: FATOXACOL, Cartagena, Colombia.
Elizabeth PazComité de Infecciones, Hospital Departamental Tomas Uribe Uribe, Tuluá, Valle del Cauca, Colombia.
Robert A BonomoDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, OH, USA.
María Virginia VillegasGrupo de Investigaciones en Resistencia Antimicrobiana y Epidemiología Hospitalaria (RAEH), Universidad El Bosque, Bogotá, Colombia.
Diego O AndreyDivision of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.ORCID https://orcid.org/0000-0003-3247-9274

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Carbapenem-resistant Gram-negative bacilli (CRGNB) pose a public health threat, increasingly driven by plasmid-mediated dissemination of carbapenemase genes. As part of a Colombian genomic monitoring programme, we aimed to characterize CRGNB co-harbouring multiple carbapenemase genes and determine their genetic context. Methods: We screened 832 carbapenem-resistant isolates collected during 2011-2023 using carbapenemase-targeted qPCR. Ten isolates co-harbouring Results: Nine Enterobacterales isolates and one Conclusions: This first report of a single plasmid co-harbouring three carbapenemase genes. This finding highlights a concerning mechanism for interspecies dissemination of MDR Gram-negative pathogens and underscores the importance of long-read genomic surveillance focused on high-risk plasmids.

Identifiers

PMID42891109
PMCPMC13673262

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