Evidence map›Paper›PMID 42891070›Full record

ArticleBrain communications2026

Correlation of blood biomarkers with microstructural brain injury in survivors of out-of-hospital cardiac arrest.

Mikael V Laaksonen, Jussi P Posti, Carita C Hollmén, Kaj Blennow, Henrik Zetterberg, Jaakko K Rinne, Sami M Virtanen, Jani P Saunavaara, Riitta K Parkkola, Ruut M Laitio and 13 more

Abstract read
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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mikael V LaaksonenDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Jussi P PostiNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Carita C HollménDepartment of Radiology, University of Turku, Turku University Hospital, 20521 Turku, Finland.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.ORCID https://orcid.org/0000-0003-3930-4354
Jaakko K RinneNeurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Sami M VirtanenDepartment of Radiology, University of Turku, Turku University Hospital, 20521 Turku, Finland.
Jani P SaunavaaraDepartment of Medical Physics, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Riitta K ParkkolaDepartment of Radiology, University of Turku, Turku University Hospital, 20521 Turku, Finland.
Ruut M LaitioDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Olli J ArolaDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Marja S HynninenDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Emmi K YlikoskiDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Juha A MartolaDepartment of Radiology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Marjaana S TiainenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.
Risto O RoineDivision of Clinical Neurosciences, University of Turku, Turku University Hospital, 20521 Turku, Finland.
Harry ScheininDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Mervyn MazeDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0001-9794-2472
Timo RoineDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, 00076 Espoo, Finland.ORCID https://orcid.org/0000-0002-3104-9734
Tero VahlbergDepartment of Biostatistics, University of Turku, 20014 Turku, Finland.
Timo T LaitioDepartment of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Xe-HYPOTHECA Working Group
Xe-HYPOTHECA Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In-hospital mortality among resuscitated out-of-hospital cardiac arrest (OHCA) patients remains high. Identifying patients who will benefit from intensive care while avoiding prolonged, potentially unnecessary treatments is essential. Blood-based biomarkers provide a novel method for evaluating brain injury. The ability of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), neuron-specific enolase (NSE) and total-tau (t-tau) to measure white and grey matter injury is unestablished in comatose OHCA survivors treated with targeted temperature management (TTM) or xenon combined with TTM. We examined correlations between the biomarkers and white and grey matter injury assessed with diffusion tensor imaging (DTI). This was a randomized, single-blind, phase 2 clinical drug trial involving two multipurpose intensive care units in Finland. It was conducted between August 2009 and March 2015. One hundred and ten comatose OHCA patients aged 24 to 76 years were randomly assigned to either inhaled xenon treatment combined with 24-h TTM (33°C) (

Indexed as

diffusion tensorneurofilament light chainout-of-hospital cardiac arrestwhite matterxenon

Identifiers

PMID42891070
PMCPMC13673109

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.