Evidence map›Paper›PMID 42891043›Full record

ArticleKidney international reports2026

Eicosanoids as Biomarkers of Hyperfiltration-Mediated Injury in CKD.

Tarak Srivastava, Ginger L Milne, Jianping Zhou, Mohammad H Rezaiekhaligh, Derek K Ng, Jennifer L Roem, Bradley A Warady, Susan L Furth, Ram Sharma, Mukut Sharma and 2 more

Abstract read
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tarak SrivastavaDivision of Nephrology, Department of Pediatrics, University of Missouri, Kansas City School of Medicine, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Ginger L MilneDepartment of Medicine, Pulmonary, Allergy, & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jianping ZhouMidwest Veterans' Biomedical Research Foundation (MVBRF), Kansas City, Missouri, USA.
Mohammad H RezaiekhalighDivision of Nephrology, Department of Pediatrics, University of Missouri, Kansas City School of Medicine, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Derek K NgDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jennifer L RoemDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Bradley A WaradyDivision of Nephrology, Department of Pediatrics, University of Missouri, Kansas City School of Medicine, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Susan L FurthDivision of Nephrology, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Ram SharmaRenal Research Laboratory, Kansas City VA Medical Center, Kansas City, Missouri, USA.
Mukut SharmaMidwest Veterans' Biomedical Research Foundation (MVBRF), Kansas City, Missouri, USA.
CKiD study investigators8
CKiD study investigators

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U24DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Derek K Ng · 2018 to 2026
$12.6M
Targeting PGE2 Receptors to attenuate shear stress-induced glomerular injuryR01DK107490 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI SRIVASTAVA, TARAK · 2016 to 2020
$2.0M
The Central Biochemistry Laboratory for the Chronic Kidney Disease in Children Cohort (CKiD)U24DK137522 · NIDDK · UNIVERSITY OF MINNESOTA · PI Jesse C Seegmiller · 2023 to 2026
$1.3M
BLRD VA I01 BX001037BLRD VA I01 BX004333NIDDK NIH HHS R01 DK107490NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U24 DK066116NIDDK NIH HHS U24 DK137522
6 · The paper itself

Abstract

Introduction: Early biomarkers of hyperfiltration-induced injury are not known. We previously reported elevated urinary prostaglandin E2 (PGE Methods: Liquid or gas chromatography-mass spectrometry was used to measure metabolites of arachidonic acid and linoleic acid (ng/mg creatinine, Results: The CKiD cohort included children with congenital anomalies of the kidney and urinary tract (CAKUT) (71%, Conclusion: We report for the first time linoleic acid-derived metabolites in children with CKD. A longitudinal study is needed to validate selected urinary eicosanoids as early biomarkers of hyperfiltration.

Indexed as

CAKUTCKD stages 2 and 3dihydroxy-octadecenoic acids (DiHOMEs)eicosanoidsglomerular diseasehyperfiltration

Identifiers

PMID42891043
PMCPMC13672976

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.