Electrospun poly(vinyl alcohol)/hyaluronic acid nanofiber mats for wound care in space: cytocompatibility and effects of UV-C treatment and simulated microgravity.

Gianluca Ciarleglio, Alessia Di Pauli, Marika Berardini, Federica Campolo, Angela Catizone, Maria Gabriella Santonicola

Abstract read

In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gianluca CiarleglioDepartment of Chemical Engineering Materials Environment, Sapienza University of Rome, Rome, Italy.

Alessia Di PauliDepartment of Anatomy, Forensic-Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy.

Marika BerardiniDepartment of Anatomy, Forensic-Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy.

Federica CampoloUnicamillus-Saint Camillus International, University of Health Sciences, Rome, Italy.

Angela CatizoneDepartment of Anatomy, Forensic-Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy.

Maria Gabriella SantonicolaDepartment of Chemical Engineering Materials Environment, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospun nanofibrous dressings are attractive for wound-care applications in space-related healthcare; however, limited information is available on the stability of UV-C-treated, water-stabilized nanofiber mats after exposure to simulated microgravity and on their cytocompatibility after pre-use treatment. To address this gap, fully aqueous poly(vinyl alcohol) (PVA) and poly (vinyl alcohol)/hyaluronic acid (PVA/HA) electrospun mats were stabilized through citric acid-mediated ester crosslinking and evaluated after UV-C treatment followed by 48 h incubation under static or simulated microgravity conditions. Both x-PVA and x-PVA/HA retained a continuous fibrous architecture without network collapse, although simulated microgravity was associated with formulation-dependent morphological remodeling. x-PVA showed a more pronounced increase in fiber diameter and a coarser network, whereas x-PVA/HA exhibited a more moderate diameter increase while retaining a highly interconnected fibrous organization. Water vapor transmission rates of 2,552.6 ± 66.7 and 2,492.6 ± 21.6 g m

Indexed as

cytocompatibilityelectrospun nanofibershyaluronic acidsimulated microgravityUV-C sterilizationwound dressing

Identifiers

PMID42890923

DOI10.3389/fbioe.2026.1946755

PMCPMC13672631

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.