Evidence map›Paper›PMID 42890790›Full record

ArticleiMetaOmics2026

Ragomics-Meta: An open-source, scalable, reproducible, and extensible multi-omics analysis workflow.

Zeping Gui, Huidong Su, Yuhao Chen, Jixing Yuan, Yexiu Gao, Ze Yu, Jing Zhang, Qingyi Zhu, Min Gu, Mulong Du and 2 more

Abstract readLetter
In one paragraph

Article in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeping GuiDepartment of Urology, Jiangsu Key Laboratory of Urological Disease Prevention and Treatment The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China.ORCID https://orcid.org/0000-0003-1537-8586
Huidong SuDepartment of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR China.
Yuhao ChenResearch and Development Department RageneBio Inc. Verona New Jersey USA.
Jixing YuanResearch and Development Department RageneBio Inc. Verona New Jersey USA.
Yexiu GaoResearch and Development Department RageneBio Inc. Verona New Jersey USA.
Ze YuResearch and Development Department RageneBio Inc. Verona New Jersey USA.
Jing ZhangResearch and Development Department RageneBio Inc. Verona New Jersey USA.
Qingyi ZhuDepartment of Urology, Jiangsu Key Laboratory of Urological Disease Prevention and Treatment The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China.
Min GuDepartment of Urology, Jiangsu Key Laboratory of Urological Disease Prevention and Treatment The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China.
Mulong DuDepartment of Urology, Jiangsu Key Laboratory of Urological Disease Prevention and Treatment The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China.
Zijie WangDepartment of Urology, Jiangsu Key Laboratory of Urological Disease Prevention and Treatment The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China.
Ming ChenResearch and Development Department RageneBio Inc. Verona New Jersey USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ragomics-Meta is an open-source, scalable, and reproducible multi-omics workflow for metabolism-centered analysis (https://www.raganetwork.com/). It integrates scRNA/snRNA-seq, spatial transcriptomics, scATAC-seq, and metabolomics modules to support quality control, dimensionality reduction, clustering, differential expression and accessibility analyses, pathway activity scoring, cell-cell communication inference, transcription-factor network analysis, and spatial metabolism exploration. By incorporating established tools such as Scanpy, Seurat, Squidpy, COMMOT, SnapATAC2, MEBOCOST, scMetabolism, AUCell, and a curated gutMGene-based resource, Ragomics-Meta enables systematic characterization of tumor metabolic programs and host-microbiome interactions. AI-assisted interpretation further facilitates biological annotation and hypothesis generation, providing a user-friendly framework for integrative single-cell and spatial multi-omics analysis.

Identifiers

PMID42890790
PMCPMC13674391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.