ArticleiMetaOmics2026
Sexual dimorphism in hormone-gut microbiome associations across reproductive states in wild giant pandas.
Article in iMetaOmics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbiota-host endocrine interactions in wild mammals remain poorly understood. Giant pandas experience seasonal dietary shifts and constrained annual reproduction, offering an ideal model to investigate microbiome-endocrine coupling. We integrated fecal hormone profiling, microsatellite-based individual identification, and gut microbiome sequencing in wild giant pandas. Microbial diversity and composition varied seasonally, with α diversity peaking during bamboo shoot-feeding. Hormonal dynamics followed predictable patterns: elevated estrogen during estrus, sustained progesterone post-estrus, and higher cortisol during leaf/stem-feeding periods. Hormone levels significantly correlated with microbial taxa and diversity, indicating coordinated microbiome-endocrine dynamics. Notably, microbiome-hormone coupling was significant in males but not in females, and males exhibited greater hormonal and microbial variability. Our findings demonstrate seasonal restructuring of gut microbiome and endocrine profiles in wild giant pandas with sex-dependent coupling, providing an integrated framework for non-invasive conservation monitoring.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.