ArticleInternational journal of nanomedicine2026
A Multifunctional Metal-Based Nanomedicine for Copper Sequestration, in situ Toxification, and Immune Activation Against Metastatic Cancer.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Tumor metastasis remains the principal cause of cancer-related mortality. However, current therapies often fail to effectively control both primary and disseminated lesions. Copper ions (Cu Methods: In this study, a multifunctional nanoplatform based on hyaluronic acid (HA)-stabilized and manganese-diethyldithiocarbamate (MnET) complex-loaded manganese dioxide (MnO Results: MMH exhibited CD44-targeted uptake, GSH- and pH-responsive drug release, and tumor-selective bioactivity. MMH efficiently scavenged Cu Conclusion: MMH would be a promising approach for treating aggressive and metastatic cancers through metal-based immunometabolic intervention.
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