ArticleACS polymers Au2026
Engineering Intramolecular Compactness in Water-Soluble Single-Chain Nanoparticles for Optimized Platinum Delivery.
Article in ACS polymers Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Single-chain nanoparticles (SCNPs) have been extensively studied for various applications, including catalysis, drug delivery, antimicrobial agents, rheology modifiers, and in nanocomposites. For catalytic applications, the collapsed polymer chain was often cross-linked using a metal complex, which also served as the active catalytic site. Inspired by the successful formation of a metal complex containing SCNPs, we have adopted this system for the delivery of the anticancer drug cisplatin. However, to deliver cisplatin into cells across the cell membrane, an understanding of the detailed structure and compactness of SCNPs is essential. In this work, we synthesized a series of statistical copolymers based on polyethylene glycol methyl ether acrylate (PEGMEA) as water-soluble monomer, 2-carboxy ethyl acrylate (CEA) as the ligand for platinum drug conjugation, and a hydrophobic monomer (methyl acrylate (MA), butyl acrylate (BA), and benzyl acrylate (BzA)) to enhance the compactness of the SCNP. The library of polymers was conjugated with cisplatin, and the resulting SCNPs were characterized predominantly by size-exclusion chromatography (SEC) with viscosity detection and small-angle X-ray scattering (SAXS), as dynamic light scattering alone is insufficient to provide information about the SCNP formation. Increasing the amount of CEA and, therefore, the amount of cisplatin reduced viscosity and the radius of gyration (
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