Evidence map›Paper›PMID 42890605›Full record

ArticleFrontiers in immunology2026

Three

Hongli Guan, Yalan Yang, Jian Li, Huan Zhang, Xue Chen, Jialiang Gao

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongli Guan *Blood Grouping Reference Laboratory, Chengdu Blood Center, Chengdu, Sichuan, China.
Yalan Yang *Blood Grouping Reference Laboratory, Chengdu Blood Center, Chengdu, Sichuan, China.
Jian LiBlood Grouping Reference Laboratory, Chengdu Blood Center, Chengdu, Sichuan, China.
Huan ZhangBlood Grouping Reference Laboratory, Chengdu Blood Center, Chengdu, Sichuan, China.
Xue ChenBlood Grouping Reference Laboratory, Chengdu Blood Center, Chengdu, Sichuan, China.
Jialiang GaoBlood Grouping Reference Laboratory, Chengdu Blood Center, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: ABO subtypes are characterized by attenuated antigen expression, rendering them susceptible to serological misclassification and posing substantial risks to transfusion safety. Splice-site variants represent one of the mechanisms underlying ABO subtype formation; however, previous mechanistic investigations have predominantly focused on the 5' splice-site(5'SS), leaving the functional consequences of 3' splice-site (3'SS) variants largely unexplored. Methods: Serological phenotyping of a proband with ABO grouping discrepancy was performed using tube agglutination, microcolumn gel agglutination, and absorption-elution assays. Genotyping was resolved by long-range PCR coupled with Nanopore sequencing. The splicing impact of this novel variant and two previously reported variants, c.29-3C>G and c.29-10T>A, was predicted Results: A novel 3'SS variant, c.29-2A>G, was identified in an Conclusion: This study provides the first direct mechanistic evidence linking

Indexed as

ABO Blood-Group SystemRNA Splice SitesRNA SplicingExonsGenotypeHumansABO Blood-Group SystemRNA Splice SitesABO subtypesantigen expressionexon skippingsplice-site variantstransfusion

Identifiers

PMID42890605
PMCPMC13672005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.