Association between Telomere Length and Idiopathic Pulmonary Fibrosis: A Case-Control Study.

Alireza Eslaminejad, Jalal Heshmatnia, Seyed Alireza Nadji, Makan Sadr, Hooman Sharifi, Reyhaneh Dehghani, Mobina Zargar, Mohsen Sadeghi

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Article in Tanaffos, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Alireza EslaminejadChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Jalal HeshmatniaChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Seyed Alireza NadjiVirology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Makan SadrVirology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hooman SharifiTobacco Prevention and Control Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Reyhaneh DehghaniSchool of Medicine, TeMS.C., Islamic Azad University, Tehran, Iran.

Mobina ZargarSchool of Medicine, TeMS.C., Islamic Azad University, Tehran, Iran.

Mohsen SadeghiChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

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6 · The paper itself

Abstract

Background: Given the poor survival of patients with idiopathic pulmonary fibrosis (IPF), it is necessary to investigate the effect of telomere length on this disease and on treatments that improve it; therefore, the purpose of the present study was to investigate the relationship between telomere length and IPF. Materials and Methods: In our case-control study, 144 participants, including 72 IPF patients admitted to Masih Daneshvari Hospital and 72 healthy controls, were selected. Blood tests were done for all subjects. Telomere length was measured using quantitative real-time PCR. The results were analyzed using SPSS version 22 software. Results: The mean telomere length in the IPF group was 0.94±0.06, which was significantly lower than that of the control group (0.97±0.03) (P<0.001). Also, there was no significant correlation between telomere length with 6-minute walk test (6MWT) (r=-0.126, P=0.296), saturated oxygen (SpO Conclusion: The results of the present study showed that IPF is an accelerated-aging disease because the telomere length index, which reflects oxidative damage, cellular turnover, and aging, is significantly reduced in these patients compared with healthy individuals of the same age.

Indexed as

Idiopathic Pulmonary FibrosisTelomereTelomere Length

Identifiers

PMID42890563

PMCPMC13671981

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