ArticleEcology and evolution2026
Selection on PER2 Phosphorylation Regulation Underlies Atypical Mammalian Circadian Rhythms.
Article in Ecology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Circadian rhythms are fundamental biological processes that enhance survival and reproductive fitness by coordinating physiology and behavior with predictable environmental cycles. However, in some species, circadian rhythms are weakened, irregular, or even undetectable, likely reflecting evolutionary responses to extreme environments or specialized ecological niches. Nevertheless, the genetic basis of these atypical phenotypes remains incompletely understood. Here, we investigated the molecular evolution of 20 PER2-associated genes across 71 representative mammalian species. We identified four genes under positive selection in mammalian lineages exhibiting atypical circadian phenotypes, three of which (
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