Evidence map›Paper›PMID 42890497›Full record

ArticlePlant direct2026

Snapshots From the Catalytic Landscape of Chalcone Isomerase.

Jason R Burke, Matthew A Rangel, Vanessa I Vasquez Meza, Hailey N Mims, Thomas O Darko, Kelwyn Ixcoy, Alfredo Ruiz Rivera, Jason Zhang, Emma R Wolf-Saxon, Chad C Moorman

Abstract read
In one paragraph

Article in Plant direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jason R BurkeDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0000-0002-2572-8298
Matthew A RangelDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0009-0000-1649-7427
Vanessa I Vasquez MezaDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0009-0008-3589-4151
Hailey N MimsDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0009-0003-0754-3606
Thomas O DarkoDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0009-0006-3148-5161
Kelwyn IxcoyDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0009-0004-4734-7113
Alfredo Ruiz RiveraDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0000-0002-4823-8056
Jason ZhangDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0009-0000-3651-7931
Emma R Wolf-SaxonDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0000-0002-2464-0219
Chad C MoormanDepartment of Chemistry and Biochemistry California State University San Bernardino San Bernardino California USA.ORCID https://orcid.org/0000-0002-2592-9735

Funding

U-RISE at CSUSBT34GM136467 · NIGMS · CALIFORNIA STATE UNIV SAN BERNARDINO · PI Leslie Renee Amodeo, Jacob D Jones · 2020 to 2026
$2.6M
NIGMS NIH HHS T34 GM136467
6 · The paper itself

Abstract

Chalcone isomerase (CHI) catalyzes the cyclization of three-ring scaffolds of flavonoids, a class of plant-based natural products important for nutrition and disease prevention. A persistent question has been whether the enzyme uses protein dynamics to facilitate conformational rearrangements of substrates within the active site. To help resolve this question, CHI from

Indexed as

chalconechalcone isomeraseenzyme dynamicsenzyme mechanismflavonoid biosynthesisnaringeninnaringenin chalcone

Identifiers

PMID42890497
PMCPMC13673511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.