Evidence map›Paper›PMID 42890486›Full record

ArticleDiabetes, obesity, and cardiometabolic CARE

Association of Weight Loss and Physical Activity With A1C Reduction in a Diabetes Prevention Program: A Secondary Analysis of a Randomized Clinical Trial.

Devin M Dishong, Benjamin Lalani, Joon Soo Kim, Daniel Zade, Aliyah Shehadeh, Mohammed S Abusamaan, Nestoras Mathioudakis, AI-DPP Study Group*

Abstract read
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In one paragraph

Article in Diabetes, obesity, and cardiometabolic CARE. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Devin M DishongDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID https://orcid.org/0009-0004-7406-6077
Benjamin LalaniDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.
Joon Soo KimDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.
Daniel ZadeDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.
Aliyah ShehadehDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.
Mohammed S AbusamaanDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.
Nestoras MathioudakisDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID https://orcid.org/0000-0002-0210-655X
AI-DPP Study Group*

Funding

Supplement to Effectiveness of Digital Versus In-Person Diabetes Prevention ProgramsR01DK125780 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MATHIOUDAKIS, NESTORAS N · 2020 to 2023
$3.0M
NIDDK NIH HHS R01 DK125780
6 · The paper itself

Abstract

objectiveWeight loss and physical activity (PA) reduce diabetes risk, but their independent contributions to A1C reduction in prediabetes are not fully quantified. This study examined the associations between weight loss, PA, and the odds of achieving A1C reduction thresholds during a lifestyle intervention. RESEARCH DESIGN AND

methodsThis secondary analysis used data from a randomized clinical trial. Participants (

resultsA dose-dependent relationship was observed between weight loss and A1C reduction. Compared with no weight loss, substantial weight loss (>5%) was associated with increased odds of lowering A1C across all thresholds (≥0.1% to ≥0.4%; odds ratio [OR] range 6.36-9.49, all

conclusionsThese findings support that weight loss may be the primary driver of improved glycemic control in individuals with prediabetes, underscoring the importance of prioritizing weight loss in lifestyle interventions.

Identifiers

PMID42890486
PMCPMC13671885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.