Evidence map›Paper›PMID 42890423›Full record

ArticleBiomedical optics express2026

Needle-injected wireless light-emitting device for 5-aminolevulinic acid-mediated photodynamic therapy of breast cancer.

Catherine G Price, Hailey S Sanders, Ana F de Almeida Barreto, Daena Talavera, Alejandro Lopez Ramirez, Sunghoon Rho, Thomas D O'Sullivan, Bradley D Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine G PriceDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.ORCID https://orcid.org/0009-0009-4018-4055
Hailey S SandersDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Ana F de Almeida BarretoDepartment of Electrical Engineering, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Daena TalaveraDepartment of Electrical Engineering, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Alejandro Lopez RamirezDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, 46656, USA.
Sunghoon RhoBioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Thomas D O'SullivanBioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana, 46556, USA.ORCID https://orcid.org/0000-0001-8662-5121
Bradley D SmithDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.ORCID https://orcid.org/0000-0003-4120-3210

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
NCATS NIH HHS UL1 TR002529
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a promising treatment for triple-negative breast cancer (TNBC), but clinical translation is limited by poor light penetration into deep-seated tumors. This study employed a miniature wireless implantable light-emitting device (WILD) for localized red-light activation of PDT after oral administration of the clinical drug 5-aminolevulinic acid (5-ALA). Cancer cell studies showed that WILD-mediated 5-ALA PDT induced phototoxicity and production of immunogenic cell death (ICD) biomarkers. Studies using a mouse model of TNBC revealed that WILD-mediated 5-ALA PDT reduced total tumor burden, with evidence suggesting immune activation. These findings support the feasibility of WILD-mediated 5-ALA PDT for treating deep-seated solid tumors.

Identifiers

PMID42890423
PMCPMC13671695

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.