Evidence map›Paper›PMID 42890412›Full record

ArticlePatient related outcome measures2026

Digital patient-reported outcomes to evaluate treatment response to filgotinib in patients with ulcerative colitis.

Leona Mazza, Lawrence Matini, Grace Dunbar, Anita Punj Sharda, Lydia White, Andrey Kormilitzin, Hanan Azzu, Sarah Cripps, Jack Sanford, Vincent Cheung and 4 more

Abstract read
In one paragraph

Article in Patient related outcome measures, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Leona MazzaFaculty of Biomedical Science, Università della Svizzera Italiana, USI Lugano, Lugano, Switzerland.ORCID https://orcid.org/0009-0001-3246-7073
Lawrence MatiniTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-6163-5371
Grace DunbarTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0009-0000-1666-9874
Anita Punj ShardaTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0009-0007-7770-2253
Lydia WhiteTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0009-0006-5001-7902
Andrey KormilitzinDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-3555-9181
Hanan AzzuPharmacy Department, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0009-0009-7702-811X
Sarah CrippsPharmacy Department, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0009-0007-1828-6747
Jack SanfordPharmacy Department, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0009-0009-8221-2907
Vincent CheungTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0000-0003-1715-2281
Oliver BrainTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-9091-8397
Timothy AmbroseTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-7976-6663
Simon Pl TravisKennedy Institute of Rheumatology, Translational Gastroenterology & Liver Unit and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-2690-4361
Alissa WalshTranslational Gastroenterology & Liver Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-8994-1186

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Patient-reported outcomes (PROs) are valuable tools for improving long-term patient outcomes and providing patient-centered care. PROs can be used to investigate real-world treatment effectiveness in patients with a chronic inflammatory disease. Methods: This was a real-world cohort study with digital patient-reported data collection by patients with ulcerative colitis (UC) using TrueColours-IBD, a web-based platform for prospective monitoring of symptoms, quality of life, and outcomes in Oxford. Effectiveness of filgotinib was compared between advanced therapy-naïve (ATN, i.e. filgotinib 1st line, Results: There were no significant differences between the ATN and ATE groups regarding clinical remission, response, and corticosteroid-free remission at any time point, with Conclusion: This study shows that PROs can serve as an important tool in evaluating real-world treatment outcomes in patients with UC using filgotinib. The results demonstrate good subjective clinical effectiveness, regardless of prior advanced therapy exposure.

Indexed as

chronic diseasecolitis, ulcerativedigital monitoringfilgotinibPatient reported outcome measures

Identifiers

PMID42890412
PMCPMC13671468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.