ArticleCureus2026
Association of Serum Ferritin and Cytokine Profile With Severity of Acute Cholecystitis in Patients Undergoing Laparoscopic Cholecystectomy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute cholecystitis is a common surgical emergency. Early assessment of disease severity is important for safe laparoscopic cholecystectomy in routine hospital practice in Pakistan. Serum ferritin and inflammatory cytokines may reflect the intensity of systemic inflammation. This study assessed their association with acute cholecystitis severity.
methodsThis observational study was conducted at Shaheed Mohtarma Benazir Bhutto Medical College, Lyari, Pakistan, over six months, starting in March 2025. Ninety-four adults with acute cholecystitis undergoing laparoscopic cholecystectomy were included by consecutive sampling. Patients were classified into Grade I, II, and III according to the Tokyo Guidelines 2018. Serum ferritin, interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-10 were measured before surgery. Complete blood count, C-reactive protein (CRP), bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were also recorded. Correlation and multivariable regression analyses were performed.
resultsOf 94 patients, 38 (40.4%) had Grade I, 39 (41.5%) Grade II, and 17 (18.1%) Grade III disease. Median ferritin increased from 146 ng/mL in Grade I to 428 ng/mL in Grade III (p<0.001). IL-6 increased from 13.2 to 56.8 pg/mL, while TNF-α increased from 10.8 to 39.5 pg/mL (both p<0.001). IL-10 increased from 6.4 to 14.2 pg/mL (p=0.002). Ferritin correlated with disease grade (r=0.64, p<0.001), while IL-6 showed the strongest correlation (r=0.72, p<0.001). After adjustment, ferritin, IL-6, and TNF-α remained independently associated with severe disease.
conclusionSerum ferritin and inflammatory cytokines, particularly IL-6 and TNF-α, were associated with increasing acute cholecystitis severity. Their use alongside routine inflammatory markers may help identify high-risk patients and support closer monitoring and better surgical planning before early laparoscopic cholecystectomy in routine hospital practice in Pakistan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.