ArticleInfection and drug resistance2026
In vitro Combinatorial Effects of 18β-Glycyrrhetinic Acid with Azole Antifungals.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the combined effects of multiple drugs and provide more therapeutic options for invasive fungal infections, this study evaluated the in vitro susceptibility of Methods: The antifungal activity of GA combined with ITC, VRC, POS, and FLU against 107 clinical isolates was evaluated using the CLSI broth microdilution method (M27-A3 and M38-A2), including 56 strains of Results: GA alone exhibited no antifungal activity. However, its combination with azoles showed complex biphasic effects. The synergistic rates of GA-POS against Conclusion: In vitro experiments demonstrate that synergistic or antagonistic effects can be observed when GA is combined with azoles. These findings deepen our understanding of the combinatorial efficacy of GA and azoles and provide new perspectives for targeted antifungal combination therapy.
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