Evidence map›Paper›PMID 42890335›Full record

ArticleInternational journal of cardiology. Heart & vasculature2026

Inter-vessel heterogeneity in coronary microvascular dysfunction: A three-vessel physiological assessment.

Mitsuhito Kunieda, Tomohiro Shimizu, Hiroyasu Uzui, Tatsuhiro Kataoka, Machiko Miyoshi, Yusuke Sato, Junya Yamaguchi, Kanae Hasegawa, Naoto Tama, Hiroyuki Ikeda and 2 more

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Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Mitsuhito KuniedaFaculty of Medical Sciences, University of Fukui, Japan.
Tomohiro ShimizuDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Hiroyasu UzuiDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Tatsuhiro KataokaDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Machiko MiyoshiDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Yusuke SatoDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Junya YamaguchiDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Kanae HasegawaDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Naoto TamaDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Hiroyuki IkedaDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Kentaro IshidaDepartment of Cardiovascular Medicine, University of Fukui, Japan.
Hiroshi TadaDepartment of Cardiovascular Medicine, University of Fukui, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronary microvascular dysfunction (CMD) is typically assessed in the left anterior descending artery (LAD); however, inter-vessel differences involving the left circumflex (LCX) and right coronary arteries (RCA) remain unclear. We investigated inter-vessel variations in CMD and their associations with patient characteristics. Methods and results: We retrospectively analyzed 91 patients (overall cohort) to evaluate patient characteristics across different coronary microvascular dysfunction (CMD) phenotypes based on physiological cutoffs: isolated CFR impairment, isolated IMR impairment, and combined impairment. Additionally, in a subgroup of 34 patients who successfully underwent physiological assessments in all three major coronary arteries (three-vessel cohort), we compared the CMD diagnostic rates between LAD-only and three-vessel assessments and evaluated vessel-specific correlations between CFR and IMR. In the Overall cohort, analysis of vessel-specific phenotypes revealed that patients with isolated IMR impairment in the LAD had a significantly higher body mass index (26.4 ± 4.90 kg/m Conclusions: Coronary microvascular physiology varies across the LAD, LCX, and RCA, indicating that conventional LAD-only assessments may underestimate CMD burden. These preliminary retrospective findings require validation in prospective, multicenter studies before routine clinical adoption.

Indexed as

Coronary flow reserveCoronary microvascular dysfunctionIndex of microcirculatory resistanceIschemia with non-obstructive coronary artery disease

Identifiers

PMID42890335
PMCPMC13671336

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