Evidence map›Paper›PMID 42890275›Full record

ArticleFrontiers in immunology2026

A candidate gonococcal outer membrane vesicle vaccine which induces persistent immunity in three genetically distinct species of mouse and is similarly immunogenic when formulated with and without aluminium adjuvant.

Ilaria Onofrio, Thomas Belcher, Molly E Quinn, Emma Lupoli, Tyler Freslov, Natasha Owen, Senuri N Dissanayake, Lukasz A Grudzein, Paula Freixeiro, Christine S Rollier and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilaria OnofrioNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Thomas BelcherNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Molly E QuinnNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Emma LupoliNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Tyler FreslovNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Natasha OwenNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Senuri N DissanayakeNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Lukasz A GrudzeinNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Paula FreixeiroNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.
Christine S RollierSchool of Biosciences, University of Surrey, Guildford, United Kingdom.
Calman A MacLennanNuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom.

Funding

NIEHS NIH HHS 27302C0028Wellcome Trust
6 · The paper itself

Abstract

Background: The escalating global incidence of multidrug-resistant Methods: We evaluated the longevity of the immune response induced by two and three doses of GonoVac formulated with aluminium hydroxide (Al(OH) Results: GonoVac with Al(OH) Conclusions: Our findings demonstrate that GonoVac, a preclinical candidate gonococcal nOMV vaccine, induces durable and functional anti-gonococcal immune responses that are higher than 4CMenB, across three commonly used laboratory strains of mice.

Indexed as

Adjuvants, ImmunologicAluminum HydroxideBacterial Outer Membrane ProteinsBacterial VaccinesGonorrheaNeisseria gonorrhoeaeAnimalsAntibodies, BacterialFemaleMiceMice, Inbred BALB CMice, Inbred C57BLAdjuvants, ImmunologicAluminum HydroxideAntibodies, BacterialBacterial Outer Membrane ProteinsBacterial Vaccinesaluminium hydroxidegonococcalgonorrhoeaimmune responselongevitymouse strainsouter membrane vesiclevaccine

Identifiers

PMID42890275
PMCPMC13672624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.