Evidence map›Paper›PMID 42890117›Full record

ArticleMolecular therapy. Nucleic acids2026

CasNano: An ultracompact CRISPR-Cas12f with a GC-rich PAM for epigenome editing with therapeutic potential.

Dongkyeong Kim, Chia-Wei Huang, Richard Pan, Junming Qian, Xuebing Wu, Orrin Devinsky, Yi-Ting Tsai, Shawn Liu

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dongkyeong KimEpitor Therapeutics, Inc., New York, NY 10032, USA.
Chia-Wei HuangEpitor Therapeutics, Inc., New York, NY 10032, USA.
Richard PanDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
Junming QianDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
Xuebing WuDepartment of Medicine and Department of Systems Biology, New York, NY 10032, USA.
Orrin DevinskyEpitor Therapeutics, Inc., New York, NY 10032, USA.
Yi-Ting TsaiEpitor Therapeutics, Inc., New York, NY 10032, USA.
Shawn LiuDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.

Funding

Application of a novel dCasNano-based Epigenetic Editing to Treat Rett SyndromeR43NS139830 · NINDS · EPITOR THERAPEUTICS, INC. · PI TSAI, YI-TING · 2024 to 2024
$698k
NINDS NIH HHS R43 NS139830
6 · The paper itself

Abstract

Clinical use of CRISPR-Cas proteins for genome engineering is constrained by their large size, limiting

Indexed as

CasMiniCRISPRaCRISPR activationCRISPR-CasDNA methylation;epigenetic editingfunctional genomicsMT: RNA/DNA Editingrett syndrome

Identifiers

PMID42890117
PMCPMC13670948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.