Evidence map›Paper›PMID 42890099›Full record

ArticleiScience2026

Microbiota-constrained bacterial density limits phage infection in the gut and allows persistence of susceptible cells.

Anouk Bertola, Nicolas Wenner, Leonardo Lemos Rocha, Timothy G Keys, Médéric Diard

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anouk BertolaBiozentrum, University of Basel, 4056 Basel, Switzerland.
Nicolas WennerBiozentrum, University of Basel, 4056 Basel, Switzerland.
Leonardo Lemos RochaBiozentrum, University of Basel, 4056 Basel, Switzerland.
Timothy G KeysBaxiva AG, Südstrasse 1, 8952 Schlieren, Switzerland.
Médéric DiardBiozentrum, University of Basel, 4056 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the rise of antibiotic resistance, bacteriophage-based treatments against bacterial infections have regained momentum. However, phage therapy has so far shown only moderate success in complex environments like the mammalian gut, where phages are particularly promising tools for microbiome engineering and specific elimination of opportunistic pathogens. Here, we use different murine models of intestinal colonization to quantitatively assess the minimal population size of susceptible

Indexed as

bacteriophageEscherichia coligut colonizationin vivo evolutionmicrobiotaphage resistance

Identifiers

PMID42890099
PMCPMC13670935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.