ArticleACS omega2026
Fluorinated Aliphatic Thiols in the Design of Cephalosporin Conjugates for Metallo-β-Lactamase Inhibition.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibiotic resistance is a major global health challenge, with the rapid spread of metallo-β-lactamase (MBL)-expressing bacteria presenting a serious clinical threat. In this study, we synthesized and investigated a series of novel cephalosporin conjugates envisioned to release MBL inhibitors upon MBL-mediated hydrolysis. The designed compounds consist of a cephalosporin core linked to trifluoromethylated aliphatic thiol-based MBL inhibitors. Conjugates releasing aliphatic thiols upon hydrolysis by the New Delhi Metallo-β-lactamase-1 (NDM-1) were identified, confirming that fluorination improves the leaving group properties of some aliphatic thiols compared to a nonfluorinated control. However, when comparing with a conjugate containing an aromatic thiol, fluorinated aliphatic thiol release appeared slower and mechanistically more complex, thus incompletely resolved. The conjugates exhibited potent inhibitory activity against several subclass B1 MBLs. In addition, the utility of
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