Evidence map›Paper›PMID 42890021›Full record

ArticleFrontiers in cellular and infection microbiology2026

Distinct time-dependent

Jayaum S Booth, Rekha R Rapaka, Monica A McArthur, Stephanie Fresnay, Thomas C Darton, Bing Guo, Claire S Waddington, Myron M Levine, Andrew J Pollard, Marcelo B Sztein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jayaum S BoothCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Rekha R RapakaDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Monica A McArthurGlobal Clinical Development, Sanofi, Swiftwater, PA, United States.
Stephanie FresnayGSK, Cambridge, MA, United States.
Thomas C DartonOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Bing GuoCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Claire S WaddingtonOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Myron M LevineCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Andrew J PollardOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Marcelo B SzteinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.

Funding

Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG) - Momi-Vax DMID #21-0004 {Supplement #6}UM1AI148684 · NIAID · EMORY UNIVERSITY · PI DAVID S STEPHENS · 2020 to 2026
$77.2M
UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SZTEIN, MARCELO B. · 2009 to 2018
$27.8M
IMMUNE MECHANISMS OF PROTECTION IN S TYPHI VACCINESR01AI036525 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1994 to 2026
$12.2M
Systems Biology and Biostatistics CoreU19AI181108 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 2024 to 2026
$8.0M
NCI NIH HHS P30 CA134274NIAID NIH HHS R01 AI036525NIAID NIH HHS U19 AI082655NIAID NIH HHS U19 AI181108NIAID NIH HHS UM1 AI148684
6 · The paper itself

Abstract

Introduction: CD8 Methods: In this study, we used specimens from a typhoid CHIM study in which participants who were immunized with live attenuated Results and discussion: Our high-dimensional profiling data showed that TD and NoTD participants followed divergent memory CD8

Indexed as

CD8-Positive T-LymphocytesPolysaccharides, BacterialSalmonella typhiTyphoid FeverTyphoid-Paratyphoid VaccinesAdolescentAdultCytokinesFemaleHuman Challenge Trials as TopicHumansImmunologic MemoryMaleMemory T CellsT-Lymphocyte SubsetsYoung AdultCytokinesPolysaccharides, BacterialTy21a typhoid vaccineTyphoid-Paratyphoid VaccinesCD8+ T cell responsecontrolled human infection model (CHIM)high dimensional profilingS. Typhi infectionTy21a immunizationtyphoid

Identifiers

PMID42890021
PMCPMC13671977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.