Evidence map›Paper›PMID 42890017›Full record

ArticleJHLT open2026

The clinical significance of baseline lung allograft dysfunction in single and bilateral lung transplant recipients.

Shahrzad M Lari, Helen Liang, Behzad Dadfar, Jin Zhou, Juhyun Kim, David Sayah, Ariss Der Hovanessian, Rajan Saggar, Michael Y Shino, Grant Turner and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shahrzad M LariDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Helen LiangDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Behzad DadfarDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Jin ZhouDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA.
Juhyun KimDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA.
David SayahDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Ariss Der HovanessianDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Rajan SaggarDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Michael Y ShinoDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Grant TurnerDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Olawale AmubieyaDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Tyler HaddadDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Ramin Salehi-RadDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Richard WatsonDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Hrishikesh S KulkarniDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Shu-Yi LiaoDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Abbas ArdehaliDepartment of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA.
John BelperioDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
S Sam WeigtDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Baseline lung allograft dysfunction (BLAD), defined as failure to achieve normal peak lung function after transplant, is associated with decreased survival in bilateral orthotopic lung transplant recipients. Limited data exist regarding the BLAD outcome in single orthotopic lung transplant (SOLT). We hypothesized that post-transplant survival in SOLT recipients with BLAD would differ according to native lung disease physiology. Methods: In our single-center retrospective cohort study, we reviewed the pulmonary function test data of 1,086 first lung transplant recipients between January 2000 and January 2020. We performed a landmark analysis examining survival landmarked at 1-year post-transplant. We used Cox proportional hazards regression to assess the baseline forced expiratory volume in one second (FEV1) percent predicted in the first year post-transplant with survival after 1 year. In SOLT patients, analysis was stratified by interstitial lung disease (ILD) and obstructive lung disease (OLD). Results: Our final cohort included 797 patients, 446 BOLT and 351 SOLT. Among SOLT patients, 263 had native ILD and 88 had native OLD. We confirmed that BLAD is associated with decreased survival in BOLT driven by BLAD grades 3 & 4. In recipients of SOLT, we found similar decreased survival with BLAD among those with native ILD, driven by grades 2, 3, & 4. However, BLAD was not associated with decreased survival in SOLT patients with native OLD, except at grade 4 (FEV1<35%). Conclusion: In SOLT recipients with native ILD, BLAD was associated with worse post-transplant survival, particularly at higher BLAD grades, similar to patterns observed in BOLT recipients. In contrast, among SOLT recipients with native OLD, variable native lung hyperinflation and mechanical effects will affect post-transplant baseline lung function with less clear implications for graft function and survival.

Indexed as

Baseline lung allograft dysfunctionBilateral lung transplantDonorPrimary graft dysfunctionPulmonary function testRecipientSingle lung transplant

Identifiers

PMID42890017
PMCPMC13670653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.