Evidence map›Paper›PMID 42889986›Full record

ArticleFrontiers in cellular and infection microbiology2026

Association analysis of CCL5, P2RX7, and SP110 gene polymorphisms with inactive pulmonary tuberculosis.

Fengting Chen, Haitao Wang, Junfeng Ren, Jifeng Cao, Chong Liu, Shanying Tong, Changdong Wu

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fengting ChenXinjiang Emergency Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Haitao WangDepartment of Respiratory Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China.
Junfeng RenDepartment of Respiratory Medicine, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, China.
Jifeng CaoXinjiang Emergency Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Chong LiuXinjiang Emergency Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Shanying TongXinjiang Emergency Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Changdong WuXinjiang Emergency Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Host genetic background plays a crucial role in Mycobacterium tuberculosis infection and the development of pulmonary tuberculosis. This study aims to investigate the association between the polymorphisms of the Methods: Identify hub genes based on GEO transcriptome data. A case-control study was conducted, enrolling 154 patients with inactive Pulmonary Tuberculosis (comprising 84 untreated and 70 treated cases) and 87 controls. Peripheral blood DNA was extracted, and six polymorphic loci within the Results: Two hub genes, Conclusions: The A allele at the

Indexed as

Chemokine CCL5Genetic Predisposition to DiseasePolymorphism, Single NucleotideReceptors, Purinergic P2X7Tuberculosis, PulmonaryAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenotypeHumansMaleMiddle AgedMinor Histocompatibility AntigensCCL5 protein, humanChemokine CCL5Minor Histocompatibility AntigensNuclear ProteinsP2RX7 protein, humanReceptors, Purinergic P2X7Sp110 protein, humanbiomarkerspulmonary tuberculosissingle nucleotide polymorphism (SNP)susceptibility genestranscriptome

Identifiers

PMID42889986
PMCPMC13671932

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.