Evidence map›Paper›PMID 42889954›Full record

ArticleLife metabolism2026

Palmitoyltransferase DHHC13 controls lysosomal cholesterol egress through palmitoylating Niemann-Pick C1.

Xiao-Ting Men, Xiao-Yu Bai, Yin-Yue Zhao, Yu-Qing Huang, Ding-Yuan Huo, Yu-Xiao Jiang, Ming-Feng Xia, Haobin Ye, Linzhang Huang, Xingrong Du and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiao-Ting MenState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Xiao-Yu BaiState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Yin-Yue ZhaoState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Yu-Qing HuangState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Ding-Yuan HuoState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Yu-Xiao JiangDepartment of Endocrinology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Ming-Feng XiaDepartment of Endocrinology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China.ORCID https://orcid.org/0000-0002-5650-0165
Haobin YeState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Linzhang HuangState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Xingrong DuState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.ORCID https://orcid.org/0000-0001-6427-9600
Hong-Jie QianDrug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai Engineering Research Center of Phase I Clinical Research and Quality Consistency Evaluation for Drugs, 366 Longchuan North Road, Shanghai 200237, China.
Shuai ChenState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, School of Medicine, Nanjing University, 12 Xuefu Road, Pukou District, Nanjing, Jiangsu 210008, China.
Qing ShiState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.
Tong-Jin ZhaoState Key Laboratory of Genetics and Development of Complex Phenotypes, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University, 2005 Songhu Road, Shanghai 200438, China.ORCID https://orcid.org/0000-0001-6861-3071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein S-palmitoylation provides a key regulatory mechanism for diverse cellular activities. Although palmitoylated proteins are frequently observed in cholesterol-enriched membrane microdomains, how protein palmitoylation reciprocally regulates cholesterol metabolism remains elusive. Here, we identify DHHC13 as a critical regulator linking protein palmitoylation to lysosomal cholesterol egress. Through an shRNA screen, we found that lack of

Indexed as

DHHC13lysosomal cholesterol egressNiemann-Pick disease type CNPC1palmitoylation

Identifiers

PMID42889954
PMCPMC13671750

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.