ArticlePostepy dermatologii i alergologii2026
Integrated multi-omics and experimental analyses identify JUNB as a candidate biomarker associated with immune-related processes in psoriasis.
Article in Postepy dermatologii i alergologii, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intoduction: Psoriasis is an immune-mediated inflammatory skin disease involving abnormal keratinocyte activation and immune infiltration, while the key transcriptional regulators underlying epidermal-immune interactions remain insufficiently defined. Aim: To identify and validate core immune-related biomarkers linked to psoriasis pathogenesis, emphasising transcription factor JUNB, through integrated bioinformatics and experimental approaches. Material and methods: Bulk transcriptome datasets (GSE14905, GSE66511, GSE154200) were examined to detect differentially expressed genes (DEGs), while three ML approaches (LASSO, random forest, and XGBoost) were used to identify hub genes. Diagnostic performance was evaluated via ROC curves. Immune infiltration patterns were assessed using CIBERSORT. Single-cell RNA-seq (GSE162183) was used for cellular localization. Results: Conclusions: These findings indicate that JUNB is closely associated with IL-17-related inflammatory responses and immune infiltration in psoriasis, providing mechanistic context for its involvement in disease pathogenesis and supporting its potential utility as a diagnostic biomarker.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.