Evidence map›Paper›PMID 42889667›Full record

ArticleVirus evolution2026

Molecular epidemiology of paediatric respiratory adenovirus infections in Île-de-France: findings from whole-genome sequencing.

Maud Salmona, Elise Diaz, Linda Feghoul, Abdeljalil Senhaji Rachik, Héloïse Delagrèverie, Honorine Fenaux, Aurélie Schnuriger, Audrey Baron, Lamia Limam, Séverine Mercier-Delarue and 2 more

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Article in Virus evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Maud SalmonaVirology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 1 av Claude Vellefaux, 75010 Paris, France.ORCID https://orcid.org/0000-0001-7985-6132
Elise DiazUniversité Paris Cité, Université Paris Cité, Biology and Pathogenesis of Viral Infection Team, INSERM UMR 1342, Saint-Louis Research Institute, 1 av Claude Vellefaux, 75010 Paris, France.
Linda FeghoulVirology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 1 av Claude Vellefaux, 75010 Paris, France.
Abdeljalil Senhaji RachikVirology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 1 av Claude Vellefaux, 75010 Paris, France.
Héloïse DelagrèverieVirology Unit, Department of Microbiology, Hôpital Avicenne, AP-HP, Bobigny  France.
Honorine FenauxVirology Department, Hôpital Paul-Brousse, AP-HP, 2 avenue Paul-Vaillant-Couturier, 94800 Villejuif, France.
Aurélie SchnurigerDepartment of Virology, Hôpitaux Saint-Antoine, Tenon, Trousseau, AP-HP, Sorbonne Université, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France.
Audrey BaronMicrobiology Laboratory, Hôpital Robert-Debré, AP-HP, Université Paris Cité, 48 boulevard Sérurier, 75019 Paris, France.
Lamia LimamVirology Department, Hôpital Paul-Brousse, AP-HP, 2 avenue Paul-Vaillant-Couturier, 94800 Villejuif, France.
Séverine Mercier-DelarueVirology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 1 av Claude Vellefaux, 75010 Paris, France.
Elyanne GaultMicrobiology Laboratory, Hôpital Ambroise-Paré, AP-HP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France.
Jérôme LeGoffVirology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 1 av Claude Vellefaux, 75010 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman adenoviruses (HAdVs) are a frequent cause of respiratory tract infections in children; however, their epidemiological patterns and genomic diversity remain insufficiently characterized in Europe. As respiratory HAdVs can cause outbreaks of acute and severe disease and show periodic re-emergence, improved understanding of their circulation is needed.

aimTo investigate the epidemiology, age distribution, and genomic diversity of respiratory HAdVs in paediatric patients in Île-de-France during the first half of 2022.

methodsWe retrospectively analysed 6 956 respiratory samples from patients < 18 years, collected at five hospitals (Jan-June 2022). HAdVs were detected by multiplex PCR. Viral loads were quantified in mono-infections, and whole-genome sequencing (WGS) was performed on samples with sufficient viral load.

resultsHAdVs were detected in 14% of samples, making them the second most prevalent virus after rhinovirus/enterovirus. Co-infections were frequent (64%), particularly in younger children. Among the 254 mono-infected samples with viral-load quantification, 110 (43%) had low or undetectable viral loads. WGS of 122 samples revealed HAdV species B (62.3%), C (34.4%), and F (3.3%). Species distribution varied by age: HAdV-C predominated in children under 2 years, while HAdV-B was more common in older children. The most frequent genotypes were B3 (76.3%), B66 (18.4%), and B7d (5.3%) within species B, and C1 (33.3%), C89 (26.2%), and C2 (23.8%) within species C.

conclusionHAdVs are prevalent among children with respiratory infections, with age-specific patterns and substantial genomic diversity. The circulation of diverse genotypes, including recombinants and potentially more virulent variants, highlights the importance of sustained molecular surveillance.

Indexed as

genomic surveillancehuman adenoviruspaediatricsrespiratory infectionswhole genome sequencing

Identifiers

PMID42889667
PMCPMC13669953

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