Evidence map›Paper›PMID 42889662›Full record

ArticleFrontiers in pediatrics2026

S100A8/A9 as a biomarker for differentiating pulmonary tuberculosis from community-acquired pneumonia in children: a multicenter cohort study in China.

Xiaoxue Li, Xu Li, Min Fang, Xiaomei Liu, Li Duan, Ming Li, Yanan Fu, Yanchun Wang, Li Jiang, Xiaotao Yang and 8 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xiaoxue Li *Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Xu Li *Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Min Fang *The No. 7 People's Hospital of Liangshan Prefecture, Liangshan, China.
Xiaomei LiuKunming Children's Hospital, Kunming Medical University, Kunming, China.
Li DuanThe No. 7 People's Hospital of Liangshan Prefecture, Liangshan, China.
Ming LiKunming Children's Hospital, Kunming Medical University, Kunming, China.
Yanan FuKunming Children's Hospital, Kunming Medical University, Kunming, China.
Yanchun WangKunming Children's Hospital, Kunming Medical University, Kunming, China.
Li JiangKunming Children's Hospital, Kunming Medical University, Kunming, China.
Xiaotao YangKunming Children's Hospital, Kunming Medical University, Kunming, China.
Tingting JiangBaoding Key Laboratory for Precision Diagnosis and Treatment of Infectious Diseases in Children, Hebei Key Laboratory of Infectious Diseases Pathogenesis and Precise Diagnosis and Treatment, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
He TangBaoding Key Laboratory for Precision Diagnosis and Treatment of Infectious Diseases in Children, Hebei Key Laboratory of Infectious Diseases Pathogenesis and Precise Diagnosis and Treatment, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
Li TanKunming Children's Hospital, Kunming Medical University, Kunming, China.
Meifen WangKunming Children's Hospital, Kunming Medical University, Kunming, China.
Yang LiuWest China Second Hospital, Sichuan University, Chengdu, China.
Yu ZhuWest China Second Hospital, Sichuan University, Chengdu, China.
Jing BiBaoding Key Laboratory for Precision Diagnosis and Treatment of Infectious Diseases in Children, Hebei Key Laboratory of Infectious Diseases Pathogenesis and Precise Diagnosis and Treatment, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China.
Adong ShenBeijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Differentiating pulmonary tuberculosis (PTB) from community-acquired pneumonia (CAP) in children remains a significant diagnostic challenge. This study aimed to evaluate the diagnostic value of serum S100A8/A9 in pediatric populations. Methods: This multicenter prospective study enrolled 1,629 children aged 0∼≤ 18 years with definitive diagnostic classifications, including a discovery cohort ( Results: In both cohorts, S100A8/A9 levels were markedly lower in PTB than in CAP but higher than in healthy controls. (both Conclusions: Serum S100A8/A9 is a promising potential biomarker for distinguishing pediatric PTB from CAP, characterized by age-related distribution and concentration-dependent diagnostic pattern.

Indexed as

biomarkerchildrencommunity-acquired pneumoniaS100A8/A9tuberculosis

Identifiers

PMID42889662
PMCPMC13670915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.